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KMID : 0370220040480020105
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Yakhak Hoeji
2004 Volume.48 No. 2 p.105 ~ p.110
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Inhibitory Effects of Dithiolo-thione Derivative SWU-20009 on Akt Activity
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고종희/Ko JH
연승우/이홍섭/김태용/노동윤/신경순/홍순광/강상순/Yeon SW/Lee HS/Kim TY/Noh DY/Shin KS/Hong SK/Kang SS
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Abstract
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Akt (or Protein Kinase B; PKB) is a serine/threonine kinase and is activated by phosphoinositide 3-kinase (PI3K) pathway: Recent evidence indicates that the abnormal activitie s or expression of Akt is closely associated with cancers diabetes and neuro- degenerative diseases. These findings mean that Akt is likely to be a new therapeutic target for the treatment of disease. Here, we screened the effects of dithiolo- dithione derivatives such as SWU-20004, SWU-20709 and SWU-20025 on Akt activities. Among these compounds , only SWU-20009 (2-Thioxo - [1,3]dithiolo[4,5- β][1,4] dithiine-5,6-dicarboxylic acid dimethyl ester) inhibited the growth of KATOIII cell at micromolar range of concentration. Further investigation also revealed that SWU- 20009 inhibited cellular Akt activity and induced apoptotic cell death.
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KEYWORD
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